Gut-Loving Polyphenols and Where to Find Them

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Gut-loving polyphenols and where to find them

Polyphenols are a diverse group of plant-chemicals found in fruits, vegetables, herbs, spices, cacao, tea, coffee and wine. I’m sure you will be familiar with the fact they are potent antioxidants, as they have been well-studied in this regard.

Today however, let’s look at a fascinating new aspect to polyphenols. That is, their beneficial action on the gut. Recent literature has shown they have remarkable prebiotic-like effects, favourably impacting the gut microbiota, consequently improving our health and wellbeing. We can get all fancy and call this the phenolic-microbiota interaction.

Polyphenols in plants: far more than antioxidants, they favourably impact the gut microbiome. More here! Click To Tweet

First of all, what are polyphenols?

Polyphenols protect plants from UV radiation, free radical damage and attack by pathogens [1]. They are micronutrients not essential to our diets but with significant health benefits. They have protective effects against cardiovascular disease, cancer and other inflammatory conditions.  Their bioactivity is largely dependent on intestinal absorption, which for the most part is poor – it is estimated that only 5-10% of dietary polyphenols pass through the small bowel [2]. Those with the best bioavailability include flavanones and isoflavones (more on these below), which encompass the citrus and soy families [1].

Gut-loving polyphenols and where to find them

Where to find them

Polyphenols can be classified as flavonoids and non-flavonoids. Flavanoids are a large subclass of polyphenols, that are in turn divided into more subclasses still. All have antioxidant activity to some degree [3]. While the root of the word flav means yellow, flavonoids can be red, blue, purple or white. Some examples;

  • Flavanols are the most widely found, rich sources being onions, garlic, curly kale, leeks, broccoli, blueberries and cacao. Green tea is perhaps the most famous in this group, containing compounds such as catechin, epicatechin, and epigallocatechin. They’re astringent, anticarcinogenic and potent antioxidants.  
  • Flavones are less common. They are found in red peppers, artichoke, celery, pomegranate and the Mediterranean herbs rosemary, parsley, thyme and oregano. These foods typically have anti-inflammatory, antibacterial and cancer protective effects, they are also effective at easing spasms.
  • Flavanones are also called bioflavonoids, and include the citrus family. Tip: it is the white pith of the fruit that is most concentrated with these compounds – and they help promote the absorption of vitamin C.
  • Proanthocyanidins are also known as condensed tannins. Cranberries are a rich source.
  • Anthocyanidins include many of the blue-purple fruits and vegetables – blackberries, blackcurrants, blueberries, cherries, cacao, cranberries, elderberries, grapes, pomegranate, purple corn, red cabbage, red onions and wine.
  • Isoflavones are found in red clover, chickpeas, flaxseeds and soy beans. This group act as phytoestrogens (plant estrogens) and play in role in prevention of osteoporosis. They also have antifungal and insecticide properties.

The non-flavanoids include phenolic acids (found in grapes, wine, strawberries, raspberries, pomegranate and walnuts), stilbenes (in blueberries, cranberries, mulberries, grapes, peanuts) and hydrolysed tannins (such as raspberry leaf, pomegranate, strawberry leaf).

[1, 3, 4].

Gut-loving polyphenols and where to find them

Of all of the above, diverse food sources of polyphenols, there are a few that have been studied for their potential benefits to digestive health. These include cacao, green tea, pomegranate, almonds, artichoke, blueberries, strawberries, apples, onions and red wine.

Polyphenols increase good bacteria, and decrease bad bacteria

Recent studies suggest that it isn’t the dietary polyphenols themselves that are influencing gut health, but rather, the metabolites produced by their breakdown into smaller parts (phenolic acids and short-chain fatty acids) by bacterial residents of the intestinal tract. This causes a favourable change in the composition of the microflora – the trillions of microorganisms inhabiting the intestinal tract, promoting the growth and diversity of beneficial bacteria (much like a prebiotic) whilst exerting selective antimicrobial effects against pathogenic bacteria [2, 5].

A few examples:

  • Cocoa flavanols have been found to increase the beneficial bifidobacterial and lactobacilli populations, and decrease pathogenic clostridium [6]
  • Green tea polyphenols have been found to decrease counts of pathogenic bacteria and increase growth of bifidobacteria and lactobacilli species [5]. Green tea extract has also been shown to reduce candida biofilms by as much as 80% [7]
  • Pomegranate, widely used in Ayurvedic medicine for its antiparasitic, antibacterial and antifungal effects, has been found in studies to inhibit gut pathogens such as salmonella, shigella, clostridia, staphyloccocus and candida [8]. It has no negative effect on the beneficial lactobacilli species and significantly promotes the growth of Bifidobacterium breve and Bifidobacterium infantis by 275% and 241% respectively [8, 9]
  • Wild blueberries, taken in powder form as a drink over six weeks resulted in an increase in Lactobacillus acidophilus and Bifidobacterium [10]
  • Red wine polyphenols have been shown to display a selective modulation of gut bacteria, promoting growth of beneficial bacteria whilst supressing pathogenic bacteria such as clostridium [5] – not that this is a license to go crazy on the wine!

Gut-loving polyphenols and where to find themGut-loving polyphenols and where to find them

What this means for our health

The ability of polyphenols to exert prebiotic-like and antimicrobial effects, suggests they could potentially be helpful in counteracting gut dysbiosis – a condition which simply means there is a microbial imbalance in the small or large bowel. Dysbiosis can greatly affect a person’s susceptibility to disease, and is associated with IBS, inflammatory bowel disease, metabolic disorders, obesity and type 2 diabetes [11]. 

Dysbiosis is something I see quite often in clinical practice, and can be induced by antibiotic use, certain medications, stress (both physical and psychological), reduced gut motility and poor diet.


Polyphenol rich foods are an incredibly beneficial part of a healthy diet, and do appear to act directly on the gut by favourably altering the composition of the microflora. My favourite ways to include them: fresh berries with porridge for breakfast, a matcha latte with a square of dark chocolate for afternoon tea, a mixture of rainbow-coloured vegetables with dinner and a glass of Dad’s homemade, organic red wine on a Sunday night!


Gut health is a particular area of interest to me professionally as a Naturopath, Medical Herbalist and Holistic Nutritionist. If you have a digestive imbalance and would like to address the root cause, come and see me in clinic.

Please visit my practitioner website for more, or make a booking via the consultations page here.

Gut-loving polyphenols and where to find them

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  1. Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004). Polyphenols: Food sources and bioavailability. The American Journal of Clinical Nutrition, 79(5), 727-747.
  2. Cardona, F., Andrés-Lacueva, C., Tulipani, S., Tinahones, F.J.,& Queipo-Ortuno, M.I. (2013). Benefits of polyphenols on gut microbiota and implications in human health. Journal of Nutritional Chemistry, 24, 1415-1422.
  3. Ganora, L. (2009). Herbal constituents. Foundations of phytochemistry. Colorado, USA. Herbalchem Press
  4. Osiecki, H. (2010). The nutrient bible (9th ed). QLD, Australia: Bio Concepts Publishing.
  5. Etxeberria, U., Fernandez-Quintela, A., Milagro, F.I., Aguirre, L., Martinez, J.A., & Portillo, M.P. (2012). Impact of polyphenols and polyphenol-rich dietary sources on gut microbiota composition. Journal of Agricultural and Food Chemistry, 61(40), 9517-9533.
  7. Evensen, N.A., & Braun, P.C. (2009). The effects of tea polyphenols on Candida albicans: Inhibition of biofilm formation and proteasome inactivation. Canadian Journal of Microbiology, 55(9), 1033-9.
  8. Pai, V., Chanu, T.R., Chakraborty, R., Raju, B., Lobo, R., & Ballal, M. (2011). Evaluation of the antimicrobial activity of Punica granatum peel against the enteric pathogens: An in vitro Asian Journal of Plant Science and Research 1(2), 57-62.
  9. Bialonskai, D., Kasimsetty, S.G., Schrader, K.K., & Ferreira, D. (2009). The effect of pomegranate (Punica granatum ) byproducts and ellagitannins on the growth of human gut bacteria. Journal of Agricultural and Food Chemistry, 57(18), 8344-8349.
  10. Vendram, S., Guglielmetti, S., Riso, P., Arioli, S., Klimis-Zacas, D., & Porrini, M. (2011). Six-week consumption of a wild blueberry powder drink increases bifidobacteria in the human gut. Journal of Agricultural and Food Chemistry, 59(24), 12815-20.
  11. Carding, S., Verbeke, K., Vipond, D.T., Corfe, B.M., & Owen, L.J. (2015). Dysbiosis of the gut microbiota in disease. Microbial Ecology in Health and Disease, 26.


Hi I’m Lauren, practising Naturopath, Medical Herbalist, Nutritionist, and essential oils educator in Auckland, New Zealand. I’m incredibly passionate about food as medicine, and helping people connect with the healing power of Nature. I’ve been sharing my recipes and health articles here since 2012.

BNatMed, AdDip NutMed, BCS, Certified FitGenes Practitioner.